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College of Sciences


Department of Chemistry and Biochemistry




Graduate Chemistry Courses

(Note:  + A lecture course having an associated laboratory)

CHEM 415/515.  Intermediate Organic Chemistry.
Lecture 3 hours; 3 credits.  Prerequisite:  CHEM 211-213 or CHEM 311-313.  An in-depth treatment of the chemistry of carbon compounds, including reaction mechanisms, spectral techniques, polymerization, pericyclic reactions, and biomolecules.

CHEM +421/521.  Instrumental Analysis Lecture.
Lecture 3 hours; 3 credits.  Prerequisite:  CHEM 333 with a grade of C or better.  Designed to be taken concurrently with CHEM 422/522.  A study of the basic principles of spectroscopic, chromatographic, and electrochemical methods of quantitative chemical analysis.  Methods of chemical instrumentation are also included.

CHEM 422/522.  Instrumental Analysis Laboratory.
Laboratory 6 hours; 3 credits.  Prerequisite:  CHEM 332W with a grade of C or better.  Pre- or corequisite:  CHEM 421/521 with a grade of C or better.  An intensive laboratory study of the principles of analytical chemistry.  Experiments in spectroscopic, chromatographic, and electrochemical methods are conducted to illustrate fundamental principles and to provide the opportunity to develop skills in the use of instrumentation for chemical measurement.

CHEM +441/541.  Introductory Biochemistry.
Lecture 3 hours; 3 credits.  Prerequisite:  CHEM 213 or 313 with a grade of C or better.  This course is a one-semester survey of the major molecular constituents, bioenergetics, enzymes, nucleic acid structure, and genetic information transfer pathways fundamental to biochemistry.

CHEM 442W/542.  Biochemistry Laboratory.
Lecture 1 hour; Laboratory 6 hours; 4 credits.  Pre- or corequisite:  CHEM 441/541 with a grade of C or better.  Prerequisites:  CHEM 213 or 214, BIOL 293, BIOL 303 with a grade of C or better.  Principles and techniques of biochemical procedures involving amino acids, protein characterization and isolation, enzymology, bioinformatics, nucleic acids, and common molecular biology techniques for DNA and RNA manipulations will be presented.  Skills in report writing and library skills are developed.

CHEM +443/543.  Intermediate Biochemistry.
Lecture 3 hours; 3 credits.  Prerequisite:  CHEM 441/541 with a grade of C or better or equivalent.  This course presents and in-depth study of protein structure, folding, and synthesis.  The major metabolic pathways will be studied in detail regarding thermodynamics and mechanism of regulation or control of individual enzymes and entire metabolic pathways.  Concepts of metabolic disease will be introduced and effects on integrated metabolism will be presented.

CHEM +451/551.  Advanced Inorganic Chemistry.
Lecture 3 hours; 3 credits.  Prerequisite:  CHEM 333 with a grade of C or better.  Theoretical aspects of modern inorganic chemistry:  bonding theories, stereochemistry, acid-base theories, coordination compounds, organometallic and bioinorganic compounds.

CHEM 452/552.  Inorganic Chemistry Laboratory.
Laboratory 4 hours; 2 credits.  Pre- or corequisite:  CHEM 451/551 with a grade of C or better.  Synthesis of metal and nonmetal inorganic compounds and organometallic compounds, their characterization by modern physical methods, and a study of their properties.

CHEM 453/553.  Essentials of Toxicology.
Lecture 3 hours; 3 credits.  Prerequisite:  CHEM 213 or 313 with a grade of C or better.  Fundamental principles of toxicology:  dose-response relationship, toxicologic testing, chemical and biological factors influencing toxicity, organ toxicology, carcinogenesis, mutagenesis, teratogenesis.

CHEM 460/560.  Frontiers in Nanoscience and Nanotechnology. 
Lecture 1 hour; 1 credit.  Nanotechnology presents unparalleled opportunities for advances in technology and medicine.  Simultaneously, nanotechnology presents new challenges to organisms and to our environment.  These undefined risk factors threaten to slow the development of new technologies and novel medical therapies.  This course will review:  structure, synthesis and properties of key nanomaterials; key applications of nanomaterials in technology and medicine; and impacts of nanomaterials on plant and animal physiology and the environment more generally.  This course will be team-taught by faculty members of Biological Sciences, Chemistry and Biochemistry, and Engineering.

CHEM 665.  Biochemistry-Biophysics Colloquium.
Lecture and discussion 1 hour; 1 credit.  Prerequisite:  permission of the instructor.  Papers from the current literature.

CHEM 669.  In-Service Practicum.
6 credits; 50 hours per credit.  Prerequisites:  CHEM 631 and CHEM 632.  One semester of work experience in local hospital, forensic, or industrial laboratory.  Available for pass/fail grading only.

CHEM 670. Graduate Orientation.
Lecture 3 hours; 3 credits. Prerequisite: instructor approval required. An introduction to graduate studies in chemistry. Topics include responsible conduct of research (RCR), grant writing skills, oral presentation of chemical research and methods for searching the chemical literature. Attendance at departmental seminars is required. Limited to first-year chemistry doctoral students.

CHEM 685-687.  Frontiers in Chemistry.
1-3 credits each semester.  Prerequisite:  permission of the department chair.  Topics representing the most recent advances in various fields of chemistry or ones which represent an interdisciplinary advancement.

CHEM 690.  Seminar.
1 credit hour.  Master’s students attend seminars given by researchers from across the country in order to expose them to additional areas of research in chemistry and biochemistry.

CHEM 691.  Master’s Seminar.
2 credits.  Master’s students attend seminars; attend a class on giving seminars; and present a seminar on their own research.

CHEM 695.  Selected Topics.
1-3 credits each semester.  Prerequisite:  permission of the department chair.

CHEM 698.  Master’s Research.
1-9 credits.

CHEM 699.  Master’s Thesis.
3 credits.

CHEM 701.  Advanced Analytical Chemistry.
Lecture 3 hours; 3 credits.  Prerequisites:  CHEM 333, 423, 424, 425 or permission of the instructor.  The theoretical foundation of analysis with emphasis on recent analytical developments and current literature.

CHEM 702.  Advanced Analytical Chemistry II.
Lecture 3 hours; 3 credits.  Prerequisites:  Instrumental Analysis (or its equivalent).  This course will review the most cutting-edge Advances Analytical Chemistry Instrumentation and Methods, spanning over three core areas of analytical chemistry (Spectroscopy, Separation and Electrochemistry) and offer the in-depth understanding of objectives, motivations, and future directions of Advanced Analytical Chemistry Instrumentation.  The course will focus on advanced instrumentation and methodologies that can achieve ultra sensitive analysis and detection, including single molecular spectroscopy, nanoparticle probes, high-speed separation in microfluidic devices, ultramicroelectrodes for sensing and imaging.

CHEM 703.  Chromatographic Separations by HPLC and GC.
Lecture 3 hours; 3 credits.  Prerequisites:  CHEM 333,  CHEM 425.  This course covers basic principles of chromatography emphasizing high performance liquid chromatography emphasizing high performance liquid chromatography (HPLC) and gas chromatography (GC), as well as separation nodes, instrumentation, detection methods, quantification, and sample preparation including solid phase extraction.  Examples from environmental sciences, biosciences and industry will be stressed.

CHEM 704.  HPLC and GC Laboratory.
Laboratory 4 or 6 hours; 2 or 3 credits.  Corequisite:  CHEM 703.  This lab course consists of six to seven independent HPLC and GC exercises based on examples from environmental, bioscience, and industrial applications.
 
CHEM 715.  Automation and Management of the Clinical Chemistry Laboratory.
Lecture 1 hour; 1 credit.  Prerequisite:  CHEM 631 or permission of the instructor.  The basic principles of management of the clinical chemistry laboratory and regulatory issues in laboratory management are presented.

CHEM 716/816.  Electrochemical Methods of Analysis.
2 credits.  Prerequisite:  CHEM 333 and CHEM 420/520, or permission of the instructor.  This course presents the fundamental principals and practical applications of modern electrochemical methods of analysis.  Lectures and text readings cover the basic concepts and fundamental principals of this division of analytical techniques.  Detailed descriptions and demonstrations of modern electrochemical research instrumentation will be provided.  Students will obtain hands-on experience with this instrumentation by performing a required chemical determination using an electroanalytical method, and by undertaking a special analytical project.  Research applications of other electroanalytical techniques and instrumentation, in addition to those actually used by the students in this course, will be discussed and/or demonstrated.

CHEM 718/818.  Chemistry of Materials.
3 credits.  Solid state band theory is approached from a molecular orbital point of view.

CHEM 720.  Experimental Design and Data Treatment.
Lecture 3 hours; 3 credits.  Prerequisite:  CHEM 321.  A hands-on approach to experimental design and multivariate data analysis.  Modern computer-based chemometric theories will be presented.

CHEM 722/822.  Bonding and Group Theory.
3 credits.  Introduction to group theory and application to problems in bonding and spectroscopy.

CHEM 723.  Modern Synthetic Organic Chemistry.
Lecture 3 hours; 3 credits.  Prerequisite:  CHEM 515 or a pass in the organic placement exam.  Design of complex organic molecules.  Tropics covered will include:  retrosynthetic analysis, stereochemical control and contemporary methods.

CHEM 724/824.  Bioinorganic Chemistry. 
3 credits.  Prerequisite:  CHEM 451/551 or equivalent.  This course is a survey of the mechanisms of biochemical activity of the trace elements.  Topics include oxygen uptake, oxidation-reduction, metabolism, and toxicity.

CHEM 725.  Physical Organic Chemistry.
Lecture 3 hours; 3 credits.  Prerequisite:  CHEM 415/515.  Approaches to the study of reaction mechanisms, including molecular orbital theory, thermochemistry, kinetics, isotop effects, solvent and substituent effects (including linear free energy relationships), acidity, acid catalysis, and detection of reactive intermediates.

CHEM 726.  Medicinal Chemistry.
Lecture 3 hours; 3 credits.  Prerequisite:  CHEM 721 or permission of the instructor.  Study of the chemistry and mode of action of various medicinal and physiologically active compounds.

CHEM 734/834.  Organic Spectroscopy.
3 credits.  Prerequisites:  CHEM 415/515 or a pass in the organic placement exam.  Organic functional group and structure analysis with ultraviolet, infrared, nuclear magnetic resonance, mass, and other spectroscopic techniques.

CHEM 736/836.  Introduction to Organic Synthesis.
3 credits.  Prerequisites:  CHEM 415/515 or a pass in the organic placement exam.  Detailed coverage of fundamental organic transformations with emphasis on reduction, oxidation, carbon-carbon bond formation, and protecting group strategy.

CHEM 741.  Stable Isotope Chemistry.
Lecture 3 hours; 3 credits.  Prerequisite:  CHEM 425.  This course investigates the stable isotope systematics of carbon, nitrogen, hydrogen, oxygen and sulfur in biological, chemical and geological systems.  Course material includes analytical methods, fractionations and applications of stable isotope analyses in a wide range of natural systems.  Recommended to graduate students in chemistry, earthy sciences and biological sciences with an interest in environmental processes.

CHEM 742/842.  Advanced Mass Spectroscopy.
3 credits.  Prerequisites:  CHEM 423/523.  This course trains students in the theory and application of advanced mass spectrometric methods as used in all subdisciplines of chemistry and biochemistry.

CHEM 743.  Organic Geochemistry.
Lecture 3 hours; 3 credits.  Prerequisite:  CHEM 313.  Organic geochemistry is the study of organic compounds originally produced by photosynthesis and altered as they cycle through the soils, atmosphere, rivers, oceans, and crustal rocks.  This course will include the carbon/oxygen cycles, biomarkers, organic matter diagenesis/catagenesis, analytical techniques used in organic geochemistry, and an introduction to carbon isotopes.

CHEM 744/844.  NMR Spectroscopy.
3 credits.  Prerequisites:  CHEM 415/515.  This course presents the basics of NMR spectroscopy.  Topics include basic NMR theory, NMR instrumentation, one- and two- dimensional 1H and 13C techniques, and introduction to solid-state NMR.

CHEM 748.  Environmental Chemistry Laboratory.
Laboratory 6 hours; 3 credits.  Prerequisite:  Chem 321 or permission of the instructor.  Study of the basic principles and methods of trace chemical analysis of environmental systems, including spectroscopic, chromatographic, and electrochemical instrumental methods, in addition to wet chemical methods.

CHEM 749.  Environmental Chemistry.
Lecture 3 hours; 3 credits.  Prerequisite:  CHEM 321.  An overview of the natural chemistry systems operating in the atmosphere, in the terrestrial environment (both water and soils), and in the oceans, and the potential effects that human activities may have on them.  Specific topics include the origin and evolution of the earth and life, the chemistry of the atmosphere (including the ozone layer and greenhouse effect), the organic and inorganic components of soil and water, chemical weathering of rocks, metal complexation, biological processes in soil and water, and global-scale chemical processes.

CHEM 754. Quantum Chemistry.
Lecture 3 hours; 3 credits. Prerequisites: CHEM 333 and instructor approval required. Overview of the development and application of quantum mechanics from a chemical perspective.

CHEM 755.  Computational Chemistry.
Lecture 3 hours; 3 credits.  Prerequisite:  CHEM 333.  Comprehensive overview of ab initio (quantum) calculations and molecular dynamic simulations, the two most widely used computational methods.  Plus a brief overview of other computational applications in chemistry and biology.

CHEM 756/856.  Inorganic Reaction Mechanisms.
3 credits.  Prerequisites:  CHEM 451/551 or equivalent.  This course is a survey of the major mechanisms of inorganic and organometallic chemistry.  Topics include kinetics, ligand substitution, electron transfer, and photochemistry.

CHEM 757/857.  Organic Chemistry Mechanisms. 
3 credits.  Prerequisites:  Chem 725/825.  The application of physical organic techniques to study the mechanisms of key organic reactions and the structures of reaction intermediates.  Includes photochemistry and pericyclic reactions.

CHEM 762/862.  Advanced Techniques in Biochemistry.
Laboratory 2-6 hours; 1-3 credits.  Prerequisites:  CHEM 541, 542, 543.  A laboratory course in modern experimental methodology and instrumentation in biochemistry.

CHEM 765.  Advanced Biochemistry.
Lecture and discussion 3 hours; 3 credits.  Prerequisites:  CHEM 541 and 543 or permission of the instructor.  Topics will include:  macromolecular structure, function, thermodynamic stability and folding kinetics; protein chemistry; molecular biology; molecular mechanisms of disease and bioinformatics.

CHEM 767.  Enzymology.
Lecture 3 hours; 3 credits.  Prerequisite:  CHEM 441/551.  Consideration of experimental methods for examining the kinetic data and rate equations from enzymes, examination of various models of enzyme catalysis, comprehensive presentation of the mechanisms of coenzyme action, and studies of mechanism of enzyme action.
 
CHEM 769.  Nucleic Acids Biochemistry.
Lecture 3 hours; 3 credits.  Prerequisite:  CHEM 541 and 543 or permission of the instructor.  A comprehensive presentation of the chemistry of RNA and DNA.  Modern concepts of gene regulation, the control over transcription, RNA processing and translation, cell cycle control and molecular carcinogenesis.

CHEM 775.  Physical Biochemistry.
Lecture 3 hours; 3 credits.  Prerequisites:  CHEM 333 and 541.  Physical characterization of macromolecules, polarized light, absorption and fluorescence, sedimentation and transport hydrodynamics, electrophoretic mobility, light scattering, and structural x-ray crystallography of proteins and nucleic acids.

CHEM 779.  Kinetics and Thermodynamics.
Lecture 3 hours; 3 credits.  Prerequisite:  CHEM 333. A survey of modern theories of reaction rates and mechanisms, classic thermodynamic functions, and an introduction to statistical thermodynamics.

CHEM 795.  Selected Topics in Chemistry and Biochemistry.
Lecture and discussion 3 hours; 3 credits.  Prerequisite:  permission of the instructor.  Thorough coverage of areas selected to meet special needs and interests.

CHEM 814-815.  Biomedical Sciences Laboratory.
2 credits each semester.  With approval of the program director.

CHEM 816.  Biomedical Sciences Laboratory.
2 credits.  With approval of the program director.

CHEM 890.  Chemistry Seminar.
1 credit.  Students attend seminars given by researchers from across the country in order to expose them to additional areas of research in chemistry and biochemistry.

CHEM 891.  Doctoral Seminar.
2 credits.  Students attend seminars; attend a class on giving seminars; and present a seminar on their own research.

CHEM 895.  Selected Topics in Biomedical Sciences.
Lecture 1-3 hours; 1-3 credits each semester.  Lecture and discussion of recent advances in the field of biomedical sciences.

CHEM 898.  Doctoral Research.
1-9 credits.

CHEM 899.  Dissertation.
1-9 credits.

CHEM 999.  Chemistry 999.
1 credit.  A one-hour pass/fail registration required of all graduate students to maintain active status during the final semester prior to graduation.  After successfully passing the candidacy examination, all doctoral students are required to be registered for at least one graduate credit each term until the degree is complete.